Oggetto: PARTNER SEARCH HEALTH-EU-SMCP-11
Richiesta di una Universitą turca alla ricerca di partner da includere in un loro progetto.
Contattare
spagnoli@apre.it, facendo riferimento al codice PARTNER SEARCH HEALTH-EU-SMCP-11
---------------------------------------------------
------- PARTNER SEARCH HEALTH-EU-SMCP-11 --------
---------------------------------------------------
<Reference n.: HEALTH-EU-SMCP-11>
<Deadline: 18/09/2007>
<Programme: >
<Project Title: De Autism in Fragile X: Microarray Identification of
FMRP Associated Mrnas and Altered Profiles Related With Methylation
Status of FMR1 Gene>
<Financial Scheme: >
<Description: Work Programme Topic: 2.2.1-10 Childhood and adolescent
mental disorders (SICA)
Aim: A number of clinical features including epilepsy, MR,
hypersensitivity to tactile stimuli, social deficits, and even loose
stools have been hypothesized to be related to enhanced mGluR5
activity and LTD in FXS. This is important for clinicians to
understand because these findings have direct therapeutic
implications. Both mGluR5 antagonists and ampakines that stimulate the
AMPA receptors are in investigational stages of development and they
have potential to be specific treatments for FXS in the future. Both
the genetic and the neural properties of FXS point out the importance
of considering the network level, not just the level of individual
genes or individual neurons. Although FXS is in one sense a
single-gene disorder, it is more proximally the result of disruption
in regulatory networks via the many genes whose transcripts FMRP
binds, and probably in many cellular processes. This very complexity
is what gives FXS the power to disrupt brain development. Similarly,
as a single-gene disorder whose analysis illuminates networks of
interacting genes and networks of interacting neurons, FXS opens for
us a route to understanding the complexity of autistic development and
a possibility of producing targeted therapies.
Recent reported data suggested that elevated FMR1 mRNA, but not CGG
repeat size or reduced FMRP (as measured by immunocytochemistry), was
significantly associated with increased autistic development such as
the other psychological symptoms in Fragile X syndrome. In this
project, it was aimed to draw a profile of mRNAs that are previously
reported as selectively associated with FMRP-mRNP complexes to
identify a subset of FMRP associated messages that play role in autism.
<Organisation Type: Universitą>
<Partner Sought: Partners are welcome from all EU, Eastern Europe,
Western Balkans and Central Asia (SICA)
- Experienced in applications of microoarray and molecular genetics.
OR
- Experienced in bioinformatics, population genetics, and microarray
data analysis
OR
- Clinicians (pediatric neurologist, neurologist, pediatric
psychiatrist or psychologist) experienced in clinical practices of
mental retardation and autism developmental disorder in children with
high patient circulation having these criteria.